Ganesh K, Wu C, …. Dow LE, Garcia-Aguilar J, Sawyers CL, Smith JJ (2019). A rectal cancer organoid platform to study individual responses to chemoradiation. Nature Medicine, October 7th, [LINK] [PDF]

Romesser PB, Kim AS, Jeong J, Mayle A, Dow LE, Lowe SW. (2019) Preclinical murine platform to evaluate therapeutic countermeasures against radiation-induced gastrointestinal syndrome. PNAS Sep 24. pii: 201906611. [PMID: 31551264] [LINK] [PDF]

Schatoff EM, Goswami S, Zafra MP, Foronda M, Shusterman M, Leach BI, Katti A, Diaz BJ, Dow LE (2019) Distinct CRC-associated APC mutations dictate response to Tankyrase inhibition. Cancer Discovery. 2019 Jul 23. pii: CD-19-0289. doi: 10.1158/2159-8290.CD-19-0289 [PMID: 31337618] [LINK] [PDF]

Schatoff EM, Paz Zafra M, Dow LE. (2019) Base Editing the Mammalian Genome. Methods. Mar 2. pii: S1046-2023(18)30318-9. doi: 10.1016/j.ymeth.2019.02.022. [PMID: 30836137] [LINK] [PDF]

Chun-Qing Song, Tingting Jiang, Michelle Richter, Luke H. Rhym, Luke W. Koblan, Maria Paz Zafra, Emma M. Schatoff, Jordan L. Doman, Yueying Cao, Lukas E. Dow, Lihua Julie Zhu, Daniel G Anderson, David R. Liu, Hao Yin, Wen Xue (2019). Adenine base editing in an adult mouse model of tyrosinaemia. Nature Biomedical Engineering.

Mishra A, Emamgholi F, Erlangga Z, Hartleben B, Unger K, Wolff K, Teichmann U, Kessel M, Woller N, Kühnel F, Dow LE, Manns MP, Vogel A, Lowe SW, Saborowski A, Saborowski M (2019) Generation of focal mutations and large genomic deletions in the pancreas using inducible in vivo genome editing. Carcinogenesis. Jun 6 [PMID: 31170286] [LINK] [PDF]

Yamamoto A, Hester J, Macklin PS, Kawai K, Uchiyama M, Biggs D, Bishop T, Bull K, Cheng X, Cawthorne E, Coleman ML, Crockford TL, Davies B, Dow LE, Goldin R, Kranc K, Kudo H, Lawson H, McAuliffe J, Milward K, Scudamore CL, Soilleux E, Issa F, Ratcliffe PJ, Pugh CW (2019) Systemic silencing of PHD2 causes reversible immune regulatory dysfunction. J Clin Invest. Jun 4;130 [PMID: 31162141] [LINK] [PDF]

Wang DG, Paddock MN, Lundquist MR, Sun JY, Mashadova O, Amadiume S, Bumpus TW, Hodakoski C, Hopkins BD, Fine M, Hill A, Yang TJ, Baskin JM, Dow LE, Cantley LC (2019) PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism. Cell Reports. Cell Rep. 2019 May 14;27(7):1991-2001.e5 [PMID: 31091439] [LINK] [PDF]

Saborowski A, Wolff K, Spielberg S, Beer B, Hartleben B, Erlangga Z, Becker D, Dow LE, Marhenke S, Woller N, Unger K, Schirmacher P, Manns MP, Marquardt JU, Vogel A, Saborowski M. (2019). Murine Liver Organoids as a Genetically Flexible System to Study Liver Cancer In Vivo and In Vitro. Hepatology Communications. Feb 5;3(3):423-436. [PMID: 30859153] [LINK] [PDF]

Garcia D, Hellberg K, Chaix A, Wallace M, Herzig S, Badur MG, Lin T, Shokhirev MN, Pinto AFM, Ross DS, Saghatelian A, Panda S, Dow LE, Metallo CM, Shaw RJ. (2019). Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD. Cell Reports. Jan 2;26(1):192-208.e6. doi: 10.1016/j.celrep.2018.12.036. [PMID: 30605676] [LINK] [PDF]


Foronda M & Dow LE (2018). CRISPR: Stressed about p53?. Trends Mol Med. 2018 Sep;24(9):731-733 [PMID: 3001753] [LINK] [PDF]

Maria Paz Zafra#, Emma M Schatoff#, Alyna Katti, Miguel Foronda, Marco Breinig, Anabel Y. Schweitzer,  Amber Simon, Teng Han, Sukanya Goswami, Emma Montgomery, Jordana Thibado, Edward R Kastenhuber, Francisco J. Sánchez-Rivera, Junwei Shi, Christopher R Vakoc, Scott W Lowe, Darjus F. Tschaharganeh, Lukas E Dow (2018). Optimized base editors enable efficient editing in cells, organoids and mice. Nature Biotechnology, Oct;36(9):888-893 [PMID: 29969439] [LINK] [PDF]

Ventura A & Dow LE (2018). Modeling cancer in the CRISPR era. Annual Reviews in Cancer BiologyVol. 2:111-131 [PDF]


Han, T, Schatoff, EM, Murphy, C, Zafra, MP, Wilkinson, JE, Elemento, O, Dow, LE (2017). R-Spondin chromosome rearrangements drive Wnt-dependent tumor initiation and maintenance in the intestine. Nature Communications. Jul 11;8:15945. doi: 10.1038/ncomms15945 [PMID: 28695896] [LINK] [PDF]

O'Rourke KP, Loizou E, Livshits G, Schatoff EM, Baslan T, Manchado E, Simon J, Romesser PB, Leach B, Han T, Pauli C, Beltran H, Rubin MA, Dow LE#, Lowe SW# (2017). Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer. Nature Biotechnology. May 1st doi: 10.1038/nbt.3837 # corresponding authors [PMID: 28459450] [LINK] [PDF]

Schatoff ES, Leach BI, Dow LE (2017). WNT Signaling and Colorectal Cancer. Curr Colorectal Cancer Rep 13: 101. doi:10.1007/s11888-017-0354-9


Zafra MP and Dow LE (2016). Somatic Genome Editing Goes ViralTrends Mol Med. Aug 20. pii: S1471-4914(16)30100-9. [   PMID: 27555346]

O'Rourke KP, Dow LE, Lowe SW (2016) Immunofluorescent Staining of Mouse Intestinal Stem CellsBio Protoc. Feb 20;6(4). pii: e1732 [PMID: 27570798]

O'Rourke KP, Ackerman S, Dow LE, Lowe SW (2016). Isolation, Culture and Maintenance of Mouse Intestinal Stem CellsBio Protoc. Feb 20;6(4). pii: e1733 [PMID: 27570799]

Lindemans CA, Mertelsmann AM, O’Connor MH, Calafiore M, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu Y, Hua G, Martin ML, O’Rourke KP, Lo Y, Mokry M, Romera-Hernandez M, Cupedo T, Dow LE, Nieuwenhuis EE2, Shroyer NF, Liu C, Kolesnick R, van den Brink MRM, and Hanash AM. (2016) Interleukin-22 Is an Intestinal Stem Cell Growth Factor Linking Immunity to Epithelial Regeneration. Nature, Dec 24;528(7583):560-4 [PMID: 26649819]


Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio II, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, Pappin DJ, Dow LE, Papadopoulos N, Gross SS, Cantley LC (2015) Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science. 2015 Nov 5. pii: aaa5004. [PMID: 26541605]

Dow LE. (2015) Modeling Disease In Vivo With CRISPR/Cas9. Trends in Molecular Medicine.  Oct; 21(10):609-21 [PMID: 26432018]

Rathert P, Roth M, Neumann T, Muerdter F, Roe JS, Muhar M, Deswal S, Cerny-Reiterer S, Peter B, Jude J, Hoffmann T, Boryn LM, Axelsson E, Schweifer N, Tontsch-Grunt U, Dow LE, Gianni D, Pearson M, Valent P, Stark A, Kraut N, Vakoc CR, Zuber J. (2015) Transcriptional Plasticity Promotes Primary and Acquired Resistance to BET Inhibition. Nature.  Sept 24;525(7570):543-547 [PMID: 26367798]

Dow LE*, O’Rourke KP*, Simon J, Tschaharganeh DF, Van Es JH, Clevers H, Lowe SW. (2015) Apc restoration promotes cellular differentiation and re-establishes crypt homeostasis in colorectal cancer. Cell.  June 18;161(7):1539-1552 [PMID: 26091037] * equal contribution

Dow LE*#, Fisher J*, O’Rourke KP, Muley A, Kastenhuber ER, Livshits G, Tschaharganeh DF, Socci N, Lowe SW#. (2015) Inducible in vivo genome editing with CRISPR/Cas9. Nature Biotechnology. [PMID: 25690852* equal contribution, #corresponding author


Bolden JE*, Tasdemir N*, Dow LE*, van Es JH, Wilkinson JE, Zhao Z, Clevers H, Lowe SW. (2014) Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition. Cell Reports. 2014 Sep 17. pii: S2211-1247(14)00688-3. * equal contribution [PMID: 25242322]

Tschaharganeh DF, Xue W, Calvisi DF, Evert M, Michurina TV, Dow LE, Banito A, Katz SF, Kastenhuber ER, Weissmueller S, Huang CH, Lechel A, Andersen JB, Capper D, Zender L, Longerich T, Enikolopov G, Lowe SW. (2014) p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer. Cell. 2014 Jul 31;158(3):579-92. [PMID: 25083869]

Dow LE, Nasr Z, Saborowski S, Ebbesen SH, Manchado E, Tasdemir N, Lee T, Pelletier J, Lowe SW (2014) Conditional Reverse Tet-Transactivator Mouse Strains for the Efficient Induction of TRE-Regulated Transgenes in Mice. PLoS One April 17, DOI: 10.1371/journal.pone.0095236 [PMID: 24743474]

Saborowski M, Saborowski A, Morris JP IV, Bosbach B, Dow LE, Pelletier J, Klimstra DS, Lowe SW. (2014) A modular and flexible ESC-based mouse model of pancreatic cancer. Genes & Development. Jan 1;28(1):85-97 [PMID: 24395249]


Premsrirut PK, Dow LE, Park Y, Hannon GJ, Lowe SW (2013). Creating Transgenic shRNA Mice by Recombinase-Mediated Cassette Exchange. Cold Spring Harb Protoc. Sep 1;2013(9) [PMID: 24003198]

Takiguchi M, Dow LE, Prier JE, Carmichael CL, Kile BT, Turner SJ, Lowe SW, Huang DC, Dickins RA (2013). Variability of Inducible Expression across the Hematopoetic System of Tetracycline Transactivator Transgenic Mice. PLoS One. 8(1):e54009. [PMID: 23326559]


Dow LE and Lowe SW (2012). Life in the fast lane: Mammalian disease models in the genomic era. Cell. Mar 16;148(6):1099-109 [PMID: 22424222]

Dow LE*, Premsrirut PK*, Zuber J*, Fellmann C, McJunkin K, Miething C, Park Y, Dickins RA, Hannon GJ, Lowe SW (2012) A pipeline for the generation of shRNA transgenic mice. Nature Protocols, Feb 2;7(2):374-93 * equal contribution [PMID: 22301776]


Pearson HB, Perez-Mancera, PA, Dow LE, Ryan A, Tennstedt P, Bogani D, Elsum I, Greenfield A, Tuveson DA, Simon R and Humbert PO (2011).  SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia, J. Clin Invest, Nov 1;121(11):4257-67 [PMID: 21695329]

McJunkin K, Mazurek A, Premsrirut PK, Zuber J, Dow LE, Simon J, Stillman B and Lowe SW (2011) Reversible suppression of an essential gene in adult mice using transgenic RNA interference. PNAS; Apr 26;108(17):7113-8. [PMID: 21482754]

Premsrirut PK*, Dow LE*, Miething C, Camiolo M, Kim SY, Malone CD, Scuoppo C, Zuber J, Dickins RA, Kogan S, Sordella R, Hannon GJ and Lowe SW (2011) A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell. Vol. 145 (1) pp. 145-58 *equal contribution [PMID: 21458673]

Zuber J, McJunkin K, Fellmann C, Dow LE, Taylor M, Hannon GJ, Lowe SW (2011). A toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi. Nat Biotech Vol. 29(1) pp.79-83 [PMID: 21131983]


Dow LE, Elsum IA, King CL, Kinross KM, Richardson HE, Humbert PO. (2008). Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signaling.  Oncogene. Oct 9;27(46):5988-6001 [PMID: 18641685]

Dow LE and Humbert PO. (2007) Polarity regulators and the control of epithelial architecture, cell migration and tumourigenesis  Int Rev Cytol.262:253-302 [PMID: 17631191]

Humbert PO, Dow LE, Russell, SM.  (2006)  The Scribble and Par complexes in the regulation of polarity and migration: Friends or Foes?  Trends in Cell Biology, Dec;16(12):622-30 [PMID: 17067797]

Dow LE, Kauffman JS, Caddy J, Peterson A, Jane SM, Russell SM, Humbert PO. (2007) The tumour suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge.  Oncogene, Apr 5;26(16):2272-82 [PMID: 17043654]

Ludford-Menting MJ, Oliaro J, Sacirbegovic F, Cheah ET, Pedersen N, Thomas SJ, Pasam A, Iazzolino R, Dow LE, Waterhouse NJ, Murphy A, Ellis S, Smyth MJ, Kershaw MH, Darcy PK, Humbert PO and Russell SM (2005) A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation. Immunity. 22:737-48 [PMID: 15963788]

Dow LE, Brumby AM, Muratore R, Coombe ML, Sedelies KA, Trapani JA, Russell SM, Richardson HE and Humbert PO. (2003). hScrib is a functional homologue of the Drosophila tumour suppressor Scribble. Oncogene 22: 9225-30 [PMID: 14681682]